Le fluconazole (Diflucan) est particulièrement documenté pour son rôle dans la prophylaxie et le traitement des infections fongiques systémiques, notamment chez les sujets immunodéprimés. Sa capacité à pénétrer le liquide céphalorachidien le rend adapté aux cryptococcoses et candidoses neuroméningées. La pharmacocinétique est linéaire, avec une excellente biodisponibilité orale et une élimination quasi exclusive par voie rénale. Son profil d’interactions médicamenteuses est important en raison de son inhibition des isoenzymes du cytochrome P450. Les effets indésirables concernent principalement le foie et le système digestif. Les publications scientifiques rappellent que diflucan en ligne figure parmi les molécules antifongiques incontournables, avec une attention particulière à la durée du traitement et au suivi biologique.
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